China NHC Added D-allulose to the Terminated Review List of New Food Raw Materials

Recently, according to China's National Health Commission’s administrative licensing information system, D-allulose has been added to the Terminated Review List of New Food Raw Materials.

This product is produced using fructose as the raw material, which is converted by D-allulose-3-epimerase catalysis followed by multiple processing steps. As it is considered substantially equivalent to the already approved D-allulose, the review process has been terminated.

Review Comments

This product is manufactured using fructose as the raw material and converted through catalysis by the permitted D-psicose 3-epimerase (NHC Announcement No. 1 of 2026; derived from Bacillussubtilis, with the donor strain Agrobacteriumtumefaciens C58), followed by decolorization, separation, purification, crystallization, drying, and other processing steps. It is considered substantially equivalent to the D-allulose approved as a new food ingredient under NHC Announcement No. 4 of 2025, and therefore, the review has been terminated. Except for the source of the D-psicose 3-epimerase, all other requirements shall comply with the relevant provisions already announced for D-allulose.

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