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    EU Amends REACH Regulation, Adds 16 New CMR Substances

    from CIRS by

    On August 11, 2025, the European Commission formally adopted Commission Regulation (EU) 2025/1731, amending Annex XVII of the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) Regulation to strengthen controls over Carcinogenic, Mutagenic, or Reproductive Toxic (CMR) substances.

    Key Amendments

    The following 16 CMR substances have been added to REACH Annex XVII:

    Substances

    EC No

    CAS No

    Hazard Classification

    ‘diuron (ISO); 3-(3,4-dichlorophenyl)-1,1-dimethylurea

    206-354-4

    330-54-1

    Carcinogen Category 1B

    ‘2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol; tetrabromobisphenol-A

    201-236-9

    79-94-7

    Carcinogen Category 1B

    ‘N,N-dimethyl-p-toluidine

    202-805-4

    99-97-8

    Carcinogen Category 1B

    ‘4-nitrosomorpholine

    -

    59-89-2

    Carcinogen Category 1B

    ‘4-methylimidazole

    212-497-3

    822-36-6

    Carcinogen Category 1B, Reproductive Toxicity Category 1B

    ‘dimethyl propylphosphonate

    242-555-3

    18755-43-6

    Mutagen Category 1B, Reproductive Toxicity Category 1B

    ‘diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

    278-355-8

    75980-60-8

    Reproductive Toxicity Category 1B

    ‘benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate

    479-100-5

    577705-90-9

    Reproductive Toxicity Category 1B

    ‘benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[phenol] (1:1)

    278-305-5

    75768-65-9

    Reproductive Toxicity Category 1B

    ‘reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate (1:1)

    -

    -

    Reproductive Toxicity Category 1B

    ‘reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol (1:1)

    -

    -

    Reproductive Toxicity Category 1B

    ‘dibutyltin maleate

    201-077-5

    78-04-6

    Reproductive Toxicity Category 1B

    ‘dibutyltin oxide

    212-449-1

    818-08-6

    Reproductive Toxicity Category 1B

    ‘reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane

    -

    -

    Reproductive Toxicity Category 1B

    ‘4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF

    216-036-7

    1478-61-1

    Reproductive Toxicity Category 1B

    ‘1,4-Benzenediamine, N,N’-mixed Ph and tolyl derivs.;

    273-227-8

    68953-84-4

    Reproductive Toxicity Category 1B

    Derogations

    Substances

    CAS No

     

    EC No

    Derogations

    Cumene

     98-82-8

    202-704-5

    As a substance on its own or as a constituent of other substances in either of the following:

    (a)   kerosene used as aviation fuel conforming to DEF STAN 91-091, ASTM specification D1655 or equivalent recognised standards and marketed under descriptions such as Jet-A, Jet-A1 or JP-(x);

    (b) gasoline used as aviation fuel conforming to DEF STAN 91-090, ASTM D910, ASTM D7547 or equivalent recognised standards.

    Regulatory Timeline

    Restrictions on the new Category 1B CMR substances will officially take effect on September 1, 2025, and apply directly across all EU member states.

    If you need any assistance or have any questions, please get in touch with us via service@cirs-group.com.

    Further Information

    Official Journal

     

      

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