UK Proposes to List Three Reproductive Toxic Substances under UK REACH Authorization List

On November 4, 2025, the UK Health and Safety Executive (HSE) proposed adding three reproductive toxic substances to the Authorization List (Annex 14) of the UK Registration, Evaluation, Authorization and Restriction of Chemicals (UK REACH) regulation and initiated a public consultation. This marks the first time the UK has proposed adding substances to the authorization list since it departed from the EU under Brexit.

Material name	EC number	CAS Number	SVHC properties	Latest Application Date (LAD)*	Sunset date
DOTE（2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate）	239-622-4	15571-58-1	Reproductive toxicity (Article 57c)	The date of inclusion in Annex 14, plus 18, 21, or 24 months.	Latest application date plus 18 months
Reaction mass of DOTE and MOTE	-	-	Reproductive toxicity (Article 57c)	The date of inclusion in Annex 14, plus 18, 21, or 24 months.	Latest application date plus 18 months.
Tetraethyllead	201-075-4	78-00-2	Reproductive toxicity (Article 57c)	The date of inclusion in Annex 14, plus 18, 21, or 24 months.	Latest application date plus 18 months.

* Please note, the exact LAD would be decided when HSE finalises the recommendation. To set this deadline, the HSE will use all relevant information available, including feedback received during the consultation.

Second Batch of Potential Regulatory Substances Disclosed

Material name	EC number	CAS number
Reaction products of 1,3,4- thiadiazolidine-2,5-dithione, formaldehyde and 4- heptylphenol, branched and linear (RP-HP) [with ≥ 0.1% w/w 4-heptylphenol, branched and linear]	No single EC number. Representative identifiers include 939-460-0 and 300-298-5.	No single CAS number. Representative identifiers include 1471311-26-8 and 93925-00-9
4,4’-bis(dimethylamino)-4”-(methylamino)trityl alcohol [with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)],	209-218-2	561-41-1

The feedback period closes on February 4, 2026. Companies operating in the UK must submit localized data on the substances’ current uses in the UK, exposure scenarios, possibilities for exemptions, and feasibility of alternatives.

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Further Information

HSE

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